Haiquan Wang

Hai-Quan Wang, PhD

PostDoc in Morphology and Developmental Biology of the Endometrium

Email: mg1835020@smail.nju.edu.cn

Phone: (+86) 25 8686 2618

Address: Nanjing Medical University, Nanjing, Jiangsu 211166, China

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Education

PhD in Clinical Medicine

Medical School, Nanjing University, 2020 - 2024

Research Direction: Endometrial cell dynamic changes and maternal-embryonic signal communications during early pregnancy

Supervisor: Professor Chaojun Li

MSc in Basic Medicine

Medical School, Nanjing University, 2018 - 2020

Research Direction: Transcriptional reprogramming and cell-cell communications during spermatogenesis in humans and mice

Supervisor: Professor Chaojun Li

BSc in Biotechnology

School of Life Sciences, Shandong Normal University, 2014 - 2018

Research Direction: I. Effects of environmental toxin polychlorinated biphenyl PCB118 in mouse reproductive system. II. Extraction and Preparation of Chlorogenic Acid.

Supervisor: Professor Shuzhen Liu, Professor Zenglan Wang

Research Highlights

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Maternal and embryonic signals cause functional differentiation of luminal epithelial cells and receptivity establishment

We found a conserved differentiation process of uterine luminal epithelium in humans and mice during early pregnancy, and proved that it can mediate maternal-embryonic communications to promote embryo implantation.

Publication: Developmental Cell (2023)
Research Image 1 Research Image 2 Research Image 3

The meiotic transcriptional reprogramming mediated by cell-cell communications in human and mice revealed by scATACseq and scRNAseq

We found a conserved meiotic reprogramming process in humans and mice, and proved that it is caused by the interactions between Sertoli cells and spermatogenic cells.

Publication: Zoological Research (2024)
Research Image 1 Research Image 2 Research Image 3

Progesterone Signaling and Endometrial Function

This review highlighted the roles of classical and non-classical progesterone receptors in endometrial receptivity and offered insights into endometriosis treatment strategies.

Publication: Chinese Journal of Cell Biology (中国细胞生物学报) (2024)

Skills

Bioinformatics Skills

Transcriptomics
Spatial transcriptomics
Single-cell and bulk ATACseq
Genomics
ChIP-seq

Programming Languages

R
Python
Linux and Shell
HTML/Css/JavaScript
MySQL

Academic Skills

Scientific Writing
Project Management
Public Speaking

Using AI

ChatGPT prompt engineering
Claude prompt engineering
Gemini prompt engineering

Publications

Hashtag (#) denotes the Co-first Authors and Asterisk (*) denotes the Corresponding Authors.

  1. Wang, H.#, Liu, Y.#, Li, D.#, Liu, J.#, Jiang, Y.# et al. Maternal and embryonic signals cause functional differentiation of luminal epithelial cells and receptivity establishment. Developmental Cell, 2023. IF=11.8
  2. Wang, H. & Li, C. The gate to metabolic crossroads. Science Bulletin, 2021. IF=18.9 Research Highlight
  3. Wang, H.#, Wu, X.#, Zhang, J.# et.al The meiotic transcriptional reprogramming mediated by cell-cell communications in human and mice revealed by single-cell ATACseq and scRNAseq. Zoological Research, 2024. IF=4.9
  4. Wang, H.#, Xiao, L.#, Sun, H.*, Li, C.* Progesterone Signaling and Endometrial Function. Chinese Journal of Cell Biology (中国细胞生物学报), 2024. Review
  5. Li, K., Wang, H., Yang, C., Li, C.*, Xue, B.* et al. Clinical implication and potential function of ARHGEF6 in acute myeloid leukemia: An in vitro study. PLoS One, 2023. IF=3.7
  6. Wu, J.#, Bu, D.#, Wang, H., Shen, D., Chong, D. et al. The rhythmic coupling of Egr-1 and Cidea regulates age-related metabolic dysfunction in the liver of male mice. Nature Communications, 2023. IF=16.6
  7. Yang, C. F.#, Liu, W. W.#, Wang, H., Zhang, J., Li, K. et al. Gonadal white adipose tissue is important for gametogenesis in mice through maintenance of local metabolic and immune niches. Journal of Biological Chemistry, 2022. IF=4.8
  8. Wu, J.#, Liu, H.#, Wang, H., Wang, Y., Cheng, Q. et al. iTRAQ-based quantitative proteomic analysis of the liver regeneration termination phase after partial hepatectomy in mice. Journal of Proteomics, 2022. IF=3.3
  9. He, Q.#, Lyu, T.#, Zhang, Y., Wang, H. et al. Effects of intrauterine exposure to 2,3′,4,4′,5‐pentachlorobiphenyl on the reproductive system and sperm epigenetic imprinting of male offspring. Journal of Reproductive Biology, 2020. IF=2.7
  10. He, Q.#, Wei X.#, Han, X., Zhou, Q., Wang, H. et al. Effects of 2,3',4,4'5-pentachlorobiphenyl exposure during pregnancy on epigenetic imprinting and maturation of offspring's oocytes in mice. Archives of Toxicology, 2019. IF=6.1
  11. Zhang, T.#, Zhu, Y.#, Wang, X., Chong, D., Wang, H. et al. Characterization of protein lactylation in relation to cardiac metabolic reprogramming in neonatal mouse hearts. Journal of Genetics and Genomics, 2024. IF=5.9
  12. Cheng, Q.#, Yuan, X.#, Lin, S., Zhao, Y., Wang, H. et al. Serum proteome profiling reveals differentially expressed proteins between subjects with metabolically healthy obesity and nonalcoholic fatty liver disease. Journal of Proteomics, 2022. IF=3.3
  13. Sang, Y., Wang, Q., Zheng, F., Hua, Y., Wang, X., Zhang, J., Li, K., Wang, H. et al. Ggps1 deficiency in the uterus results in dystocia by disrupting uterine contraction. Journal of Molecular Cell Biology, 2021. IF=5.5
  14. Chong, D., Gu, Y., Zhang, T., Xu, Y., Bu, D., Chen, Z., Xu, N., Li, L., Zhu, X., Wang, H. et al. Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming. Cell Discovery, 2022. IF=13
  15. Liu, C., Zuo, W., Yan, G., Wang, S., Sun, S., Li, S., Tang, X., Li, Y., Cai, C., Wang, H. et al. Granulosa cell mevalonate pathway abnormalities contribute to oocyte meiotic defects and aneuploidy. Nature Aging, 2023. IF=16.6
  16. Sang, Y., Yang, Q., Guo, Y., Liu, X., Shen, D., Jiang, C., Wang, X., Li, K., Wang, H. et al. Oocytes orchestrate protein prenylation for mitochondrial function through selective inactivation of cholesterol biosynthesis in murine species. Journal of Biological Chemistry, 2023. IF=4.8
  17. Wang, X., Zhang, X., Sang, Y., Chong, D., Sheng, X., Wang, H. et al. The neonatal ketone body is important for primordial follicle pool formation and regulates ovarian ageing in mice. Life Metabolism, 2022. IF=N/A

Presentations

Poster

The meiotic transcriptional reprogramming mediated by cell-cell communications in human and mice revealed by single-cell ATACseq and scRNAseq

The 6th World Congress of Reproductive Biology, Beijing (2023)

Awards and Honors

  • China Optics Valley Scholarship, Nanjing University (2023)
  • First-Class Scholarship, Nanjing University (2018-2024)
  • National Scholarship, Shandong Normal University (2016)
  • First-Class Outstanding Student Scholarship, Shandong Normal University (2014-2018)

News

  • November 2024: Wang began his postdoctoral fellowship at Nanjing Drum Tower Hospital.
  • June 2024: Wang successfully completed his Ph.D. dissertation defense.
  • April 2024: After four months of revisions, our work was published in Zoological Research .