Haiquan Wang

Hai-Quan Wang, PhD

PostDoc in Morphology and Developmental Biology of the Endometrium

Email: mg1835020@smail.nju.edu.cn

Phone: (+86) 25 8686 2618

Address: Nanjing Medical University, Nanjing, Jiangsu 211166, China

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Education

PhD in Clinical Medicine

Medical School, Nanjing University, 2020 - 2024

Research Direction: Endometrial cell dynamic changes and maternal-embryonic signal communications during early pregnancy

Supervisor: Professor Chaojun Li

MSc in Basic Medicine

Medical School, Nanjing University, 2018 - 2020

Research Direction: Transcriptional reprogramming and cell-cell communications during spermatogenesis in humans and mice

Supervisor: Professor Chaojun Li

BSc in Biotechnology

School of Life Sciences, Shandong Normal University, 2014 - 2018

Research Direction: I. Effects of environmental toxin polychlorinated biphenyl PCB118 in mouse reproductive system. II. Extraction and Preparation of Chlorogenic Acid.

Supervisor: Professor Shuzhen Liu, Professor Zenglan Wang

Research Highlights

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Maternal and embryonic signals cause functional differentiation of luminal epithelial cells and receptivity establishment

We found a conserved differentiation process of uterine luminal epithelium in humans and mice during early pregnancy, and proved that it can mediate maternal-embryonic communications to promote embryo implantation.

Publication: Developmental Cell (2023)
Research Image 1 Research Image 2 Research Image 3

The meiotic transcriptional reprogramming mediated by cell-cell communications in human and mice revealed by scATACseq and scRNAseq

We found a conserved meiotic reprogramming process in humans and mice, and proved that it is caused by the interactions between Sertoli cells and spermatogenic cells.

Publication: Zoological Research (2024)
Research Image 1 Research Image 2 Research Image 3

Progesterone Signaling and Endometrial Function

This review highlighted the roles of classical and non-classical progesterone receptors in endometrial receptivity and offered insights into endometriosis treatment strategies.

Publication: Chinese Journal of Cell Biology (中国细胞生物学报) (2024)

Skills

Bioinformatics Skills

Transcriptomics
Spatial transcriptomics
Single-cell and bulk ATACseq
Genomics
ChIP-seq

Programming Languages

R
Python
Linux and Shell
HTML/Css/JavaScript
MySQL

Academic Skills

Scientific Writing
Project Management
Public Speaking

Using AI

ChatGPT prompt engineering
Claude prompt engineering
Gemini prompt engineering

Publications

Hashtag (#) denotes the Co-first Authors and Asterisk (*) denotes the Corresponding Authors.

  1. Wang, H.#, Liu, Y.#, Li, D.#, Liu, J.#, Jiang, Y.# et al. Maternal and embryonic signals cause functional differentiation of luminal epithelial cells and receptivity establishment. Developmental Cell, 2023. IF=11.8
  2. Wang, H. & Li, C. The gate to metabolic crossroads. Science Bulletin, 2021. IF=18.9 Research Highlight
  3. Wang, H.#, Wu, X.#, Zhang, J.# et.al The meiotic transcriptional reprogramming mediated by cell-cell communications in human and mice revealed by single-cell ATACseq and scRNAseq. Zoological Research, 2024. IF=4.9
  4. Wang, H.#, Xiao, L.#, Sun, H.*, Li, C.* Progesterone Signaling and Endometrial Function. Chinese Journal of Cell Biology (中国细胞生物学报), 2024. Review
  5. Li, K., Wang, H., Yang, C., Li, C.*, Xue, B.* et al. Clinical implication and potential function of ARHGEF6 in acute myeloid leukemia: An in vitro study. PLoS One, 2023. IF=3.7
  6. Wu, J.#, Bu, D.#, Wang, H., Shen, D., Chong, D. et al. The rhythmic coupling of Egr-1 and Cidea regulates age-related metabolic dysfunction in the liver of male mice. Nature Communications, 2023. IF=16.6
  7. Yang, C. F.#, Liu, W. W.#, Wang, H., Zhang, J., Li, K. et al. Gonadal white adipose tissue is important for gametogenesis in mice through maintenance of local metabolic and immune niches. Journal of Biological Chemistry, 2022. IF=4.8
  8. Wu, J.#, Liu, H.#, Wang, H., Wang, Y., Cheng, Q. et al. iTRAQ-based quantitative proteomic analysis of the liver regeneration termination phase after partial hepatectomy in mice. Journal of Proteomics, 2022. IF=3.3
  9. He, Q.#, Lyu, T.#, Zhang, Y., Wang, H. et al. Effects of intrauterine exposure to 2,3′,4,4′,5‐pentachlorobiphenyl on the reproductive system and sperm epigenetic imprinting of male offspring. Journal of Reproductive Biology, 2020. IF=2.7
  10. He, Q.#, Wei X.#, Han, X., Zhou, Q., Wang, H. et al. Effects of 2,3',4,4'5-pentachlorobiphenyl exposure during pregnancy on epigenetic imprinting and maturation of offspring's oocytes in mice. Archives of Toxicology, 2019. IF=6.1
  11. Zhang, T.#, Zhu, Y.#, Wang, X., Chong, D., Wang, H. et al. Characterization of protein lactylation in relation to cardiac metabolic reprogramming in neonatal mouse hearts. Journal of Genetics and Genomics, 2024. IF=5.9
  12. Cheng, Q.#, Yuan, X.#, Lin, S., Zhao, Y., Wang, H. et al. Serum proteome profiling reveals differentially expressed proteins between subjects with metabolically healthy obesity and nonalcoholic fatty liver disease. Journal of Proteomics, 2022. IF=3.3
  13. Sang, Y., Wang, Q., Zheng, F., Hua, Y., Wang, X., Zhang, J., Li, K., Wang, H. et al. Ggps1 deficiency in the uterus results in dystocia by disrupting uterine contraction. Journal of Molecular Cell Biology, 2021. IF=5.5
  14. Chong, D., Gu, Y., Zhang, T., Xu, Y., Bu, D., Chen, Z., Xu, N., Li, L., Zhu, X., Wang, H. et al. Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming. Cell Discovery, 2022. IF=13
  15. Liu, C., Zuo, W., Yan, G., Wang, S., Sun, S., Li, S., Tang, X., Li, Y., Cai, C., Wang, H. et al. Granulosa cell mevalonate pathway abnormalities contribute to oocyte meiotic defects and aneuploidy. Nature Aging, 2023. IF=16.6
  16. Sang, Y., Yang, Q., Guo, Y., Liu, X., Shen, D., Jiang, C., Wang, X., Li, K., Wang, H. et al. Oocytes orchestrate protein prenylation for mitochondrial function through selective inactivation of cholesterol biosynthesis in murine species. Journal of Biological Chemistry, 2023. IF=4.8
  17. Wang, X., Zhang, X., Sang, Y., Chong, D., Sheng, X., Wang, H. et al. The neonatal ketone body is important for primordial follicle pool formation and regulates ovarian ageing in mice. Life Metabolism, 2022. IF=N/A

Presentations

Poster

Title: The meiotic transcriptional reprogramming mediated by cell-cell communications in human and mice revealed by single-cell ATACseq and scRNAseq

The 6th World Congress of Reproductive Biology, Beijing (2023)

Title: Maternal and embryonic signals cause functional differentiation of luminal epithelial cells and receptivity establishment

2025 Annual Meeting of Chinese Society for Cell Biology, Zhuhai (2025), EXCELLENT POSTER AWARD

Awards and Honors

  • China Optics Valley Scholarship, Nanjing University (2023)
  • First-Class Scholarship, Nanjing University (2018-2024)
  • National Scholarship, Shandong Normal University (2016)
  • First-Class Outstanding Student Scholarship, Shandong Normal University (2014-2018)

News

  • November 2024: Wang began his postdoctoral fellowship at Nanjing Drum Tower Hospital.
  • June 2024: Wang successfully completed his Ph.D. dissertation defense.
  • April 2024: After four months of revisions, our work was published in Zoological Research .